![]() ![]() Within each harvest season, conventional and organic whole fruits were compared for marketable qualities (fruit weight, specific gravity, peel thickness, and peel color), and juices were compared for marketable qualities (specific gravity, % juice, and color), human health-bioactive compounds (minerals, ascorbic acid, lycopene, sugars, pectin, phenols, and nitrates), and consumer taste intensity and overall acceptance. Whole grapefruits from each production system were harvested between 8 h at commercial early (November), mid- (January), and late season (March) harvest periods for three consecutive years. The aforementioned production variables common to both production systems were matched for comparison of Texas commercially grown conventional and certified organic Rio Red red-fruited grapefruit. ![]() This is due mainly to a lack of rigor in research studies matching common production variables of both production systems, such as microclimate, soil type, fertilizer elemental concentration, previous crop, irrigation source and application, plant age, and cultivar. 2013 143(6):818-826.Most claims that organic produce is better tasting and more nutritious than nonorganic (conventional) produce are largely unsubstantiated. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Medium-term effects of dietary nitrate supplementation on systolic and diastolic blood pressure in adults: a systematic review and meta-analysis. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Webb AJ, Patel N, Loukogeorgakis S, et al. Nutrients and nutraceuticals for the Management of High Normal Blood Pressure: an evidence-based consensus document. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.Ĭicero AFG, Grassi D, Tocci G, Galletti F, Borghi C, Ferri C. Besides suggesting more complex mechanisms, there is potential for maximising the clinical benefit of dietary nitrate and targeting isolated systolic hypertension.īlood pressure cytochrome p450 nitric oxide. Grapefruit juice enhanced beetroot juice's effect on lowering SBP and PP despite decreasing plasma. The taste score of Beet+GFJ was 1.4/10 points higher than Beet+H 2 O (P =. 006), as was salivary nitrite production (P =. Contrary to the hypothesis, plasma was lower with Active Beet+GFJ vs Active Beet+H 2 O (P =. Peak mean differences in SBP and PP were seen at T = 5 hours: -3.3 mmHg (95% confidence interval -6.43 to -0.15) and at T = 2.5 hours: -4.2 mmHg (95% CI -0.3 to -8.2), respectively. The addition of grapefruit juice to active beetroot juice lowered systolic BP (SBP): Active Beet+GFJ vs Active Beet+H 2 O (P =. We performed a randomized, placebo-controlled, 7-hour crossover study in 11 healthy volunteers, attending on 3 occasions, receiving: a 70-mL shot of active beetroot juice (Beet-It) and either (i) 250 mL grapefruit juice (Active Beet+GFJ), or (ii) 250 mL water (Buxton, Active Beet+H 2 O) or (iii) Placebo Beet+GFJ. We therefore hypothesized that grapefruit juice would enhance BP-lowering with beetroot juice by maintaining circulating. Grapefruit juice contains the CYP3A4 inhibitor furanocoumarin. Cytochrome P450-3A4 inhibition with troleandomycin prevents nitrite re-oxidation to nitrate in rodent liver. However, NO and nitrite are inactivated via reoxidation to nitrate, potentially limiting their activity. ![]() Dietary nitrate from sources such as beetroot juice lowers blood pressure (BP) via the nitrate-nitrite-nitric oxide (NO) pathway. ![]()
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